Samenvatting
Het doel van dit proefschrift is het onderzoeken van de neurale mechanismen, die ten grondslag liggen aan neuroticisme, om beter te begrijpen waarom hoog scorende mensen op deze persoonlijkheidstrek kwetsbaarder zijn om psychiatrische stoornissen te ontwikkelen. Om dit doel te bereiken, hebben we meta-analytische, neuroimaging en genetic imaging studies uitgevoerd. Tijdens rust zien we al dat de hersenen van hoog scorende mensen op neuroticisme een andere functionele netwerkorganisatie hebben, dan die van laag scorende mensen. Om precies te zijn, laten we zien dat subnetwerken gerelateerd aan het verwerken van emoties een prominentere rol spelen binnen het netwerk van deze hoog scorende mensen, dan subnetwerken die deze emoties juist moeten reguleren en cognitief controleren. Dit zien we ook terug in de resultaten van de meta-analyse en de taken die wij hebben onderzocht. Verder vonden we ook dat genen wellicht een effect hebben op de functionele netwerkorganisatie, tevens in associatie met neuroticisme. Samenvattend, de bevindingen van dit proefschrift kunnen mogelijkerwijs i) meer licht werpen op de relatie tussen neuroticisme en psychiatrische stoornissen en ii) helpen bij het ontwikkelen van meer toegespitste behandelingen, die kunnen voorkomen dat hoog scorende mensen op neuroticisme een transitie maken van een gezonde staat naar een klinische staat.
| Vertaalde titel van de bijdrage | Neuroticisme en het brein |
|---|---|
| Originele taal-2 | English |
| Kwalificatie | Doctor of Philosophy |
| Toekennende instantie |
|
| Begeleider(s)/adviseur |
|
| Datum van toekenning | 18-feb.-2015 |
| Plaats van publicatie | [S.l.] |
| Uitgever |
|
| Gedrukte ISBN's | 978-90-367-7374-4 |
| Elektronische ISBN's | 978-90-367-7373-7 |
| Status | Published - 2015 |
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Titles and contents Final publisher's version, 678 KB
Chapter 1 Final publisher's version, 637 KB
Chapter 2 Final publisher's version, 1,83 MB
Chapter 3 Final publisher's version, 1,97 MB
Chapter 4 Final publisher's version, 1,52 MB
Chapter 5 Final publisher's version, 2,69 MB
Chapter 6 Final publisher's version, 2,59 MB
Chapter 7 Final publisher's version, 683 KB
Chapter 8 Final publisher's version, 1,38 MB
Chapter 9 Final publisher's version, 1,07 MB
Chapter 10 Final publisher's version, 933 KB
Complete dissertationFinal publisher's version, 10,8 MB
PropositionsFinal publisher's version, 513 KB
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Servaas, M. (2015). Neuroticism and the brain: Neuroimaging and genetic imaging studies on the personality trait neuroticism. [Thesis fully internal (DIV), Rijksuniversiteit Groningen]. [S.n.].
Servaas, Michelle. / Neuroticism and the brain : Neuroimaging and genetic imaging studies on the personality trait neuroticism. [S.l.] : [S.n.], 2015. 281 blz.
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title = "Neuroticism and the brain: Neuroimaging and genetic imaging studies on the personality trait neuroticism",
abstract = "The aim of the current thesis was to investigate the neural mechanisms underlying neuroticism to gain insight into why individuals scoring high on this personality trait are more vulnerable to develop psychopathology. To this end, we conducted a series of meta-analytic, neuroimaging and genetic imaging studies. During rest (i.e. when the brain is in default mode), we found that the network organization of high (compared to low) neurotic individuals is organized less optimally with regard to efficient information processing and shows signs of functional disconnectivity. In addition, we demonstrated that subnetworks related to emotion and salience processing play a more prominent role in the network organization of high neurotic individuals, while subnetworks related to sensory(-motor) functions and cognitive control play a less prominent role. This was also observed in the results of our meta-analysis and tasks that we investigated. Furthermore, we found that genetic markers, namely 5-HTTLPR and COMT, have an impact on the functional network organization, also in interaction with neuroticism. In conclusion, the findings may help explain why high (compared to low) neurotic individuals have an increased risk of developing psychopathology and may increase the knowledge for developing treatments that will prevent these individuals from transiting from a healthy state to a clinical state.",
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Servaas, M 2015, 'Neuroticism and the brain: Neuroimaging and genetic imaging studies on the personality trait neuroticism', Doctor of Philosophy, Rijksuniversiteit Groningen, [S.l.].
Neuroticism and the brain: Neuroimaging and genetic imaging studies on the personality trait neuroticism. / Servaas, Michelle.
[S.l.]: [S.n.], 2015. 281 blz.
Onderzoeksoutput
TY - BOOK
T1 - Neuroticism and the brain
T2 - Neuroimaging and genetic imaging studies on the personality trait neuroticism
AU - Servaas, Michelle
PY - 2015
Y1 - 2015
N2 - The aim of the current thesis was to investigate the neural mechanisms underlying neuroticism to gain insight into why individuals scoring high on this personality trait are more vulnerable to develop psychopathology. To this end, we conducted a series of meta-analytic, neuroimaging and genetic imaging studies. During rest (i.e. when the brain is in default mode), we found that the network organization of high (compared to low) neurotic individuals is organized less optimally with regard to efficient information processing and shows signs of functional disconnectivity. In addition, we demonstrated that subnetworks related to emotion and salience processing play a more prominent role in the network organization of high neurotic individuals, while subnetworks related to sensory(-motor) functions and cognitive control play a less prominent role. This was also observed in the results of our meta-analysis and tasks that we investigated. Furthermore, we found that genetic markers, namely 5-HTTLPR and COMT, have an impact on the functional network organization, also in interaction with neuroticism. In conclusion, the findings may help explain why high (compared to low) neurotic individuals have an increased risk of developing psychopathology and may increase the knowledge for developing treatments that will prevent these individuals from transiting from a healthy state to a clinical state.
AB - The aim of the current thesis was to investigate the neural mechanisms underlying neuroticism to gain insight into why individuals scoring high on this personality trait are more vulnerable to develop psychopathology. To this end, we conducted a series of meta-analytic, neuroimaging and genetic imaging studies. During rest (i.e. when the brain is in default mode), we found that the network organization of high (compared to low) neurotic individuals is organized less optimally with regard to efficient information processing and shows signs of functional disconnectivity. In addition, we demonstrated that subnetworks related to emotion and salience processing play a more prominent role in the network organization of high neurotic individuals, while subnetworks related to sensory(-motor) functions and cognitive control play a less prominent role. This was also observed in the results of our meta-analysis and tasks that we investigated. Furthermore, we found that genetic markers, namely 5-HTTLPR and COMT, have an impact on the functional network organization, also in interaction with neuroticism. In conclusion, the findings may help explain why high (compared to low) neurotic individuals have an increased risk of developing psychopathology and may increase the knowledge for developing treatments that will prevent these individuals from transiting from a healthy state to a clinical state.
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Servaas M. Neuroticism and the brain: Neuroimaging and genetic imaging studies on the personality trait neuroticism. [S.l.]: [S.n.], 2015. 281 blz.
